Nā huahana
5-Fluorocytosine
Hui Pū ʻIa
Kikino
Ke ʻano: ʻO ka pauka keʻokeʻo
Mānoanoa: 1.3990 (manaʻo)
Ka helu hehee: 298-300 °C (Dek.) (kumu)
Lae paila.
Hoʻopaʻapaʻa
Kuhikuhi uila.
ʻIkepili Palekana
Māhele pōʻino.
Helu lawe waiwai weliweli.
Māhele ʻeke.
Palapala noi
Hoʻohana ʻia ka Flucytosine ma ka waha no ka mālama ʻana i nā maʻi koʻikoʻi i hoʻokumu ʻia e nā maʻi maʻalahi o Candida a i ʻole Cryptococcus neoformans.Hiki ke hoʻohana ʻia no ka mālama ʻana i ka chromomycosis (chromoblastomycosis), inā maʻi nā maʻi maʻi.ʻAʻole pono e hoʻohana ʻia ʻo Flucytosine ma ke ʻano he mea hoʻokahi i nā maʻi fungal weliweli ma muli o nā hopena antifungal nāwaliwali a me ka hoʻomohala wikiwiki ʻana o ke kū'ē, akā i ka hui pū ʻana me ka amphotericin B a / a i ʻole nā antifungal azole e like me fluconazole a itraconazole.Hiki ke mālama ʻia nā maʻi liʻiliʻi e like me ka candidal cystitis me ka flucytosine wale nō.I kekahi mau ʻāina, ʻo ka mālama ʻana me ka infusion intravenous lohi no ka ʻoi aku o hoʻokahi pule he koho therapeutic nō hoʻi, inā he mea weliweli ka maʻi.
Hiki ke loaʻa nā maʻi fungal koʻikoʻi i ka poʻe immunocompromised.Loaʻa kēia poʻe i ka lāʻau hui pū me ka flucytosine, akā ʻoi aku ka kiʻekiʻe o ka hopena o nā hopena ʻaoʻao o ka lāʻau hui pū, me ka amphotericin B.
Hoʻohana ʻia ka 5-Fluorocytosine e mālama i nā maʻi fungal i hoʻokumu ʻia e Cryptococcus a me Candida, e like me ka fungal sepsis, endocarditis, maningitis, a me nā mea antifungal no nā maʻi māmā a me nā maʻi urinary tract.
ʻano ʻano
He hana antifungal kiʻekiʻe kēia huahana e kūʻē iā Candida spp.a me Candida spp.a he hana antibacterial kekahi e kū'ē iā Bacillus spp.a me Mycobacterium spp.ʻO ka huahana he antibacterial ma ka haʻahaʻa haʻahaʻa a me ka fungicidal ma ke kiʻekiʻe kiʻekiʻe.ʻO ke ʻano o ka hana ke kāohi ʻana i ka synthesis o ka waikawa nucleic fungal.He mea maʻalahi ka haʻuki e hana i ke kū'ē i kēia huahana.
Hoʻomalu
Hoʻohui pū ʻia me ka amphotericin B, loaʻa ka hopena synergistic, akā hiki ke hōʻemi i ka excretion o kēia huahana mai ka puʻupaʻa a hoʻonui i ke kahe koko, kahi e hoʻoulu ai i nā hopena ʻawaʻawa i ka ʻōpū a me ke koko.No laila, pono e nānā a mālamaʻia ka piko o ke koko ma 50-75μg / ml,ʻaʻole iʻoi aku ma mua o 100μg / ml;hiki i ka hoʻohana ʻana i nā mea hoʻopaneʻe iwi iwi ke hoʻonui i ka ʻona hematologic o kēia huahana.
Hiki i kēia huahana ke hoʻoulu i ka ① nausea, ka maʻi maʻi, ka ʻūlū, a me nā mea ʻē aʻe;② pōʻino o ke akepaʻa, ʻoi aku ka nui o nā hōʻailona hana o ka ate, akā he hepatomegaly a i ʻole hepatic necrosis;③ myelosuppression leukocyte a me ka ho'ēmi platelet, hiki i kekahi manawa ke kumu i ka cytopenia koko holoʻokoʻa.Ua hōʻike pū ʻia ka hemahema o ka granulocytic leukocyte a me ka hoʻokuʻu ʻana i ka anemia;④ ua hōʻike pū ʻia nā hallucinations, ke poʻo a me ka vertigo.No laila, e hoʻohana me ka akahele i nā mea maʻi me ka hepatic a i ʻole renal impairment, nā maʻi koko, a me ka hoʻopau ʻana i ka iwi iwi.Pono ke nānā mau ʻia ke kiʻi o ke koko peripheral, ka ate a me ka hana kīkī a me ka hana mimi i ka wā e hoʻohana ai i kēia huahana.Loaʻa iā ia ka hopena teratogenic i ka hoʻāʻo holoholona, a pono e hoʻohana me ka akahele i nā wahine hāpai.
ʻO nā hopena maikaʻi ʻole e pili ana i nā transaminases kiʻekiʻe, alkaline phosphatase, nā hōʻailona o ka ʻōpū, leukopenia, anemia, thrombocytopenia, hōʻemi i ka renal, headache, emi ʻana o ka ʻike maka, hallucinations, lohe nalo, dyskinesia, hoʻemi i ka serum potassium, calcium a me ka phosphorus waiwai, a me nā hopena maʻi (eg rash) .
