Nā huahana
Polyinosinic Acid-polycytidylic Acid
Hui Pū ʻIa
Kikino
Nānā: keʻokeʻo a keʻokeʻo paha
ʻO ka mānoanoa.
Lae hehee.
Lae paila.
Hoʻopaʻapaʻa
Kuhikuhi uila.
ʻIkepili Palekana
Māhele pōʻino.
Helu lawe waiwai weliweli.
Māhele ʻeke.
Palapala noi
Ua ʻike ʻia ʻo Poly I: C e launa pū me ka mea hoʻokipa e like me ka toll-like 3 (TLR3), i hōʻike ʻia ma ka membrane endosomal o nā cell B, macrophages a me nā cell dendritic.Ua like ke ano o ka Poly I:C me ka RNA kaulua, aia i kekahi mau ma'i a he mea hooikaika kino ia o TLR3.No laila, hiki ke noʻonoʻo ʻia ʻo Poly I: C he analog synthetic o ka RNA stranded pālua a he mea hana maʻamau no ka noiʻi ʻepekema ma ka ʻōnaehana pale.
ʻano ʻano
ʻO kēia huahana he mea hoʻokomo interferon synthetic, he polyribonucleotide pālua ʻelua i haku ʻia me ka polyinosinic acid a me ka polycytidylic acid.No ka mea he ʻano ʻano ʻano interferon, paʻakikī ka hoʻomākaukau ʻana i nā mea nui no ka noi lapaʻau, no laila ua hoʻohana nui ʻia ma ke ʻano he interferon inducer e hoʻoulu i ka interferon.Eia kekahi, hiki i ka polyinosinic acid ke kuleana o ka immune adjuvant, hiki ke hoʻoulu i ka ʻōnaehana reticuloendothelial, hoʻonui i ka hana phagocytic o nā phagocytes, hoʻonui i ka hoʻokumu ʻana o nā antibodies, hoʻoulu i ka hopena allograft a hoʻopaneʻe i ka hopena maʻi.Loaʻa iā ia nā hopena antiviral a me antitumor ākea ākea.
Hoʻohana a me nā ʻano hana synthesis
Nānā nui
ʻO ka polycytidylic acid, ka mea i kapa ʻia he polyinosinic acid, polyhypoxanthine nucleotide a me polycytidine nucleotide, ʻo ia kekahi o nā polynucleotides, aia i kahi kaulahao polynucleotide pālua ʻelua o ka polyinosinic acid a me ka polycytidylic acid, me ke ʻano decolorization a me ka helu heheʻe, a paʻa i -20 ℃ .
Nā hopena lāʻau lapaʻau
1. He hopena hoʻolaha maikaʻi ko ka polyinosinic acid ma luna o ke kino ʻokoʻa a me ka ʻole o ke kino.
(1) Hoʻonui nā polymyocytes i ka hana o nā pūnaewele immune
(2) Paipai nā Polymyocytes i ka huna ʻana o nā cytokines like ʻole
(3) Induction o Mx protein e nā polymyocytes
(4) Paipai nā polymyocytes i ka hana ʻana o nā antibodies i loko o vivo
2. Ka hopena anti-viral o nā polymyocytes
Ua hōʻike ʻia nā hoʻokolohua in vitro, nā hoʻāʻo holoholona a me nā hoʻokolohua lapaʻau kanaka he nui nā hopena antiviral polymyxins, me ka maʻi maʻi yellow fever, encephalomyelitis virus, Rift Valley fever virus, avian influenza virus, hepatitis virus, AIDS virus, wāwae-a-waha. ma'i ma'i, ma'i conjunctivitis, ma'i ma'i ma'alahi, ma'i virus Mengo, ma'i ma'i pox, ma'i myocarditis, ma'i Aleutian, ma'i virus coxsackie, etc.
Palapala noi
1. He homopolymer kaulua i hiki ke hoʻohana ʻia ma ke ʻano he RNA hoʻohālike e aʻo ai i ka hōʻailona cell ma ke kiʻekiʻe o TLR3 e ʻike ana i ka RNA kaulua pālua, ʻo ia hoʻi ka hopena nui o ka pane kūlohelohe i nā pathogens viral.
2.Paired me ka polyinosinic acid e hana i ka polyinosinic cell, hoʻohana ʻia no ka mālama ʻana i ka maʻi hepatitis viral, herpes zoster, herpes simplex keratitis, herpes stomatitis, epidemic hemorrhagic fever, etc.
3. Loaʻa iā ia ka hopena adjuvant immune, hoʻoulu i ka ʻōnaehana reticuloendothelial, hoʻonui i ka phagocytosis, hoʻonui i ka hana antibody, hoʻoulu i ka hopena allograft a hoʻopaneʻe i ka hopena maʻi.Loaʻa iā ia ka hopena antiviral ākea a me ka hopena antitumor.Hoʻohana nui ʻia no ka: pale a mālama ʻana i nā maʻi viral, mālama ʻana i ka herpes zoster, herpetic keratitis, viral hepatitis.ʻO ka mālama ʻana i nā maʻi maʻi maʻi.ʻO ka hopena maikaʻi ʻole, ʻo ia ka hypothermia transient a me nā hihia o ke kuni kiʻekiʻe ma luna o 38 ℃, ka hapa nui o ka emi ʻana i loko o 1-2 mau lā.Inā ʻaʻole i emi ke kuni i loko o 2 mau lā, pono e hoʻopau koke ʻia ka lāʻau lapaʻau.ʻIke pū ʻia ka nāwaliwali, ka waha maloʻo, ka ʻūlū, ka nausea, etc.
