I kēia mau lā, ua ʻike nā mea noiʻi mai Georgia State University a me Tufts University e hiki i ka folic acid ke hoʻoulu i ka hoʻonui ʻana o nā cell stem ma o ka moʻomeheu in vitro a me nā ʻōnaehana hoʻohālike holoholona, ʻaʻole i hilinaʻi ʻia i kāna hana ma ke ʻano he huaora, a ua paʻi ʻia ka noiʻi kūpono i ka puke pai honua. Pūnaehana hoʻomohala.
ʻO ka ʻakika Folic, inā he huaola B hoʻonui a i ʻole ka waikawa folic maoli i hoʻokumu ʻia mai ka meaʻai, pono ia no ka hana maʻamau o nā cell āpau i loko o ke kino a he mea koʻikoʻi ia i ka pale ʻana i nā hemahema o ka ulu ʻana o nā keiki hou.I loko o ka ʻatikala, ua ʻike mua nā mea noiʻi e hiki ke hoʻomalu ʻia ka heluna o nā cell stem makua e kahi mea i loaʻa mai waho o ke kino holoholona, ʻo ia hoʻi, ka waikawa folic mai ka bacteria, e like me nā ʻano nematodes e like me Caenorhabditis elegans.
Ua ʻōlelo ka mea noiʻi ʻo Edward Kipreos, ʻo kā mākou haʻawina e hōʻike ana e hiki ke hoʻokaʻawale ʻia nā cell stem germ i ka caenorhabditis elegans e ka folate stimulation mai ka meaʻai bacteria;ʻO ka waikawa folic he huaʻa B pono, akā ua ʻike nā mea noiʻi ʻaʻole hiki ke hilinaʻi i ka hiki o ka folic acid kūikawā e hoʻoulu i nā cell germ i kāna hana ma ke ʻano he huaʻa B, kahi e hōʻike ai he hana pololei ka folic acid ma ke ʻano he mole hōʻailona.
Hiki mai ka waikawa folic maoli i loko o nā ʻano kemika, e like me ka waikawa folic i ka meaʻai a i ʻole ke ʻano metabolically active o ka folic acid i loko o ke kino o ke kanaka, a aia pū kekahi folic acid i kahi ʻano synthetic nui i nā meaʻai paʻa a me nā mea hoʻohui huaora.Uaʻikeʻia ka waikawa folic i ka makahiki 1945, mai ka lā i loaʻa ai, ua aʻo nui nā mea noiʻi iā ia, a i kēia manawa aia ma mua o 50,000 mau pepa noiʻi e pili ana i ka folic acid, akāʻoi aku ka kūikawā o kēia haʻawina, no ka mea, hōʻike ka haʻawina i kahi hana hou. o ka waikawa folic, ma mua o ke kuleana o ka waikawa folic i hōʻike ʻia ma nā haʻawina mua.
Hoʻohui ʻia ka folic acid i kēia manawa i nā cereals ma ʻAmelika Hui Pū ʻIa a me nā ʻāina ʻē aʻe, a hiki i ka hoʻonui ʻana i ka waikawa folic ke kōkua nui i ka hoʻohaʻahaʻa ʻana i ka hānau ʻana o nā pēpē me nā hemahema hoʻomohala neural tube, akā ʻo ke kuleana o ka folic acid o ka hilinaʻi ʻole i nā huaora ke kōkua i ka hāʻawi ʻana i ke ala lua e hiki ai. ke kino kanaka.I loko o ka ʻatikala, ua ʻike nā mea noiʻi he pono ka folate receptor kūikawā i kapa ʻia ʻo FOLR-1 e hoʻoulu i ka ulu ʻana o nā pūnaewele reproductive i loko o ke kino o Caenorhabditis elegans.
I ka manawa like, ua nānā nā mea noiʻi i ke kaʻina hana o nā mea hoʻokipa FOLR-1 e hoʻolaha ana i nā maʻi maʻi germ cell i caenorhabditis elegans, e like paha me ke kaʻina hana o ka folic acid receptors e hoʻoulu ai i ka holomua o nā maʻi maʻi kūikawā i loko o nā kino kanaka;ʻoiaʻiʻo, ʻaʻole pono nā mea loaʻa no ka lawe ʻana i ka waikawa folic i loko o nā cell no ka hoʻohana ʻana i ka huaora, akā hiki iā lākou ke hoʻoulu i ka māhele cell.ʻO ka mea hope loa, ʻōlelo ka poʻe noiʻi e hāʻawi pū ka haʻawina iā mākou i kahi mea hana hou e kōkua ai i ke aʻo ʻana i nā ʻano mea hoʻohālike genetic.
Ka manawa hoʻouna: Mar-30-2022