3,3'- diindolylmethane

ʻO ka wehewehe pōkole:

ʻO 3,3′- diindolylmethane (3,3′-diindolylmethane) he keʻokeʻo a kokoke i ke keʻokeʻo crystalline pauka, hiki ke hoʻoheheʻe ʻia i ka methanol, ethyl acetate, dichloromethane a me nā mea hoʻoheheʻe ʻē aʻe.3,3′- ʻo ka methane diindole i loko o nā mea kanu maoli o Cruciferae.He hana koʻikoʻi koʻikoʻi a me ka lāʻau lapaʻau a hoʻohana nui ʻia i ka lāʻau lapaʻau a me nā huahana olakino.ʻO 3,3′-diindolylmethane (DIM) ka hua hoʻoheheʻe nui o indole-3-carbinol, kahi mea anticancer i loko o nā mea kanu cruciferous.ʻO 3,3′-diindolylmethane (DIM) he mea kū'ē ikaika ia o ka loaʻa Android maʻemaʻe (AR).

E hoʻouna i ka leka uila iā mākou

Huahana Huahana

wehewehe

ʻO ka 3,3'-diindolylmethane kahi mea waena lāʻau lapaʻau;Hiki ke loaʻa iā ia i loko o nā phytochemical kūlohelohe no nā mea kanu Cruciferae, nā huahana hopena catalyzed acid, indole-3-methanol;Loaʻa iā ia ka hana o ka anti-tumor agent;Ma lalo o ke kūlana o ka manaʻo kiʻekiʻe, ʻaʻole hiki i ka derivative ke hoʻolalelale wale i ka apoptosis o nā pūnaewele maʻi maʻi kanaka, akā e hoʻoikaika i ke ala e hoʻoulu ai i ka apoptosis o nā maʻi kanesa kanaka;Ke hoʻoulu nei ʻo Chemicalbookdim i ka hoʻopaʻa ʻana o ke apo G1 i ka maʻi maʻi umauma kanaka MCF-7 ma o ka mīkini a me ka ʻōlelo hoʻohui;ʻO Dim kahi mea hoʻopaneʻe ikaika o ka mitochondrial h+-atpase;Ma ke ʻano he mea hoʻoulu ulu mea kanu hou, ua hoʻohana ʻia ka dim a me kāna mau mea i hoʻohana ʻia i ka noiʻi ʻōnaehana pili kaiaola.

ʻIke Huahana

Ka helu helu: 1968-05-4

Maʻemaʻe: ≥98%

Kumu:C17H14N2

Kumu Wt.：246.31

Inoa Kemika:3,3'-Diindolylmethane

Manaʻo like ： :3,3'-Diindolylmethane(DIM);Di(1H-indol-3-yl);Plant:Indole;3,3'-DIINDOLYLMETHANE,>=98%(HPLC);3,3'-METHYLENEBIS- 1H-INDOLE;3,3'-METHYLENEBISINDOLE;3,3'-METHYLENEDIINDOLE;3,3'-DIINDOLYLMETHANE

Lae hehee:167 °C

Lahi paila:230 °C

Hoʻoheheʻe: Chloroform (Sparingly), Methanol (Liʻiliʻi)

ʻAno: ʻO ka pauka keʻokeʻo

Hoʻouna a mālama

Paʻa ka mālama ʻana i ka mahana mālama ʻia -20°C.

Hoʻomākaukau E kau i ka indole (1.17 g, 10 mmol), CTAB (50% mol) a me ka ʻakika oxalic (50% mol) i loko o ka 25 ml ʻāʻī hoʻokahi poʻe poʻe lalo, hoʻohui i 5 ml wai deionized, hoʻoulu maikaʻi no 5 min a laila. e hoʻohui i ka wai formaldehyde wai (0.38 g solution, 5 mmol formaldehyde) i ka hāʻule.E hana no 3 mau hola ma ka lumi wela a ho'ōki i ka hopena.Ua unuhi ʻia ka hopena hopena me 15 ml o ka ethyl acetate i ʻekolu mau ʻāpana, a ua hōʻiliʻili ʻia ka māhele organik a maloʻo me ka anhydrous Na2SO4 no 5 mau hola.Ua wehe 'ia ka mea ho'ohehe'e ma lalo o ke kaomi ho'emi 'ia a ho'iho'i hou 'ia mai ka hui 'ana o ka methanol a me ka wai (methanol/H2ChemicalbookO = 10/1) no ka hā'awi 'ana i kahi pa'a ke'oke'o 3,3'-diindolylmethane ma 85% hua.ʻO Bioactivity3,3'-Diindolylmethane (DIM) ka huahana digestion nui o indole-3-carbinol, he mea anticancer hiki ke loaʻa i nā mea kanu cruciferous. .
Ua hōʻike ʻia nā haʻawina in vitro he radioprotector a me ka mitigator maikaʻi ʻo DIM, e hana ana ma ka hoʻoulu ʻana i nā pane e like me DDR-e like me ka NF-κB ola hōʻailona. e like me AKT, NF-κB a me FOXO3.Hiki iā ia ke pale i ka hōʻike ʻana o ka estrogen-induced gene a hoʻoulu i ke koʻikoʻi endoplasmic reticulum.Hiki i ka chemicalbookDIM ke hoʻololi i ka metabolism estrogen a hoʻohālikelike i ka hana ʻana o ka estrogen a me ka androgen receptor.Ua hōʻike ʻia nā haʻawina vivo he kūpono ka DIM e kūʻē i ka radiation systemic ma hope o nā lawelawe he nui.I nā hoʻokolohua in vivo, hāʻawi ʻo DIM i ka pale radiation a i ʻole mitigation.Ma nā ʻiʻo maʻamau, hoʻāla ʻo DIM i ka ATM.Hiki ke hāʻawi ʻia ka dIM i nā ʻiole e ka hoʻopiha waha (250 mg/kg) me ka bioavailability kiʻekiʻe a ʻaʻohe t acute.

Mua: ʻO ka mea kūʻai aku o Kina Indole

Aʻe: ʻO Kina Indole-3-methanol mea kūʻai aku