Nā huahana
2,6-Di-tert-butyl-4-methylpyridine
Hui Pū ʻIa
Nānā: keʻokeʻo acicular crystal
Māmā: 1,476 g/cm3
Ka helu hehee: 31-32 ℃
Puni paila: 148-153 ℃ (12.6kPa)
Hōʻike manaʻo hoʻohālikelike: N20 /D 1.4763(māmā)
Kekahi uila: 183 °F
Nā kūlana mālama: 2-8°C
ʻAkika helu helu (pKa): 6.88±0.10(Wanamua)
ʻIkepili Palekana
No ka ukana nui
Code dute: 2942000000
Laki ʻauhau ʻauhau no waho (%) : 13%
Palapala noi
Organic synthetic intermediate, kahi kumu i hoʻopaʻa ʻia, non-nucleophilic e hoʻokaʻawale ana ma waena o Brnsted (protonic) a me Lewis acid.Hiki ke hoʻololi pololei i nā aldehydes1 a me nā ketones1,2 i vinyl triflates.
ʻO 2,6-Di-tert-butyl-4-methylpyridine he mea hoʻohui me ka molecular formula C14H23N, he mea koʻikoʻi koʻikoʻi i ka synthesis organik, hoʻohana nui ʻia i nā intermediates pharmaceutical, synthesis organik, nā mea hoʻoheheʻe organik, hiki ke hoʻopili ʻia i ka hana dye, pesticide. hana a me nā mea ʻala, etc.
Hana hana
1. E hana i 2,6 di-tert-butyl-4-methylbenzyl trifluoromethanesulfonate I loko o ka pahu kolu 100-mL i hoʻolako ʻia me ka paipu hoʻokomo naikokene, ka pahu hoʻokomo mau, ka pahu hoʻoulu electromagnetic a me ka condenser hau me ka paipu maloʻo, e hoʻohui i 24.2 g (0.2 mol) o trimethylethyl phthalide chloride a me 3.7 g (0.05 mol) o tert-butanol.Ua hoʻomehana ʻia ka hui ʻana i loko o ka ʻauʻau ʻaila i 85 ° C.A laila ua hoʻohui ʻia ka 15 g (0.1 mol) o ka trifluoromethanesulfonic acid no ka ʻoi aku ma mua o 15 mau minuke.Ua hoʻomau ʻia ka hopena no 10 mau minuke, a ua hoʻomaha ʻia ka huahana ʻulaʻula māmā i loko o ka ʻauʻau hau a ninini ʻia i loko o 100 ml o ka etera anuanu.Ua kānana ʻia ka ʻeleʻele ʻeleʻele a maloʻo no ka loaʻa ʻana o 9.6 g (54%) o ka paʻakai buzz lohi.(ʻAʻole koi ʻia ka hoʻomaʻemaʻe: no ka ʻanuʻu aʻe o ka hoʻomākaukau ʻana, e hana hou i ʻelua manawa mai ka chloroform a i ka carbon tetrachloride 3:1) i nā kristal like ʻole o ka nila.
2. Hoʻomākaukau ʻana i ka 2,6-Di-tert-butyl-4-methyl-vizine Ma lalo o ka hoʻoulu ʻana, ua hoʻokuʻu ʻia kahi hoʻomaha o 10 g (0.028 mol) o ka paʻakai maʻemaʻe o ka vizine i loko o 200 mL o 95% ethanol i hoʻomaloʻo ʻia i 60 ° C. Hoʻohui ʻia i hoʻokahi manawa i ka 100 mL o ka amonia paʻa i hoʻomaloʻo ʻia i 60 ° C i loko o ka ipu 1-lita o ka māla-lalo.Ua hoʻomauʻia ka hopena ma 60 ° C no 30 mau minuke a me 40 ° C no 2 mau hola, i ia manawa ua hoʻopauʻia ka hoʻomaha.A laila, ninini ʻia ka hui ʻana i loko o 500 ml o 2% sodium hydroxide solution i hoʻomehana mālie ʻia i ka lumi wela.Wehe 'ia me ka .4-100 ml o ka pentana, hui 'ia i hui 'ia, 25 ml o saturated sodium chloride solution holoiia, 100 ml o ka pentane rotary evaporator concentration.
